Hypercholesterolemic Aortic-Valve Disease
نویسندگان
چکیده
منابع مشابه
Development of Aortic Valve Disease in Familial Hypercholesterolemic Swine: Implications for Elucidating Disease Etiology
BACKGROUND Familial hypercholesterolemia (FH) is a prevalent hereditary disease associated with increased atherosclerosis and calcific aortic valve disease (CAVD). However, in both FH and non-FH individuals, the role of hypercholesterolemia in the development of CAVD is poorly understood. This study used Rapacz FH (RFH) swine, an established model of human FH, to investigate the role of hyperch...
متن کاملCalcific aortic valve stenosis in old hypercholesterolemic mice.
BACKGROUND Hypercholesterolemia and old age are clinical risk factors for development of aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target. We tested the hypothesis that calcification and aortic valve stenosis would develop in genetically hypercholesterolemic old mice. METHODS AND RESULTS Twenty-four low-density lipoprotein receptor-deficient apolipoprotein B-10...
متن کاملFibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice.
OBJECTIVE Hypercholesterolemia and hypertension are associated with aortic valve stenosis (AVS) in humans. We have examined aortic valve function, structure, and gene expression in hypercholesterolemic/hypertensive mice. APPROACH AND RESULTS Control, hypertensive, hypercholesterolemic (Apoe(-/-)), and hypercholesterolemic/hypertensive mice were studied. Severe aortic stenosis (echocardiograph...
متن کاملCalcific Aortic Valve Disease
Despite the high prevalence and severe consequences of calcific aortic valve disease (CAVD), its pathogenesis remains relatively poorly understood. For many years, CAVD was considered a degenerative disease, where calcification was a consequence of normal aging. Although it is now widely accepted that CAVD is an active disease process, the erroneous degenerative label contributed to delayed pro...
متن کاملBicuspid aortic valve disease.
Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect. While the BAV can be found in isolation, it is often associated with other congenital cardiac lesions. The most frequent associated finding is dilation of the proximal ascending aorta secondary to abnormalities of the aortic media. Changes in the aortic media are present independent of whether the valve is functio...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2003
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmc031360